Effect of phenoclor DP6 on enzyme-altered foci and lipid peroxidation in livers of aflatoxin B1-initiated rats.

Abstract

This study investigates the capacity of phenoclor DP6 to promote aflatoxin B1 (AFB1)-induced putative preneoplastic foci in the liver. In male Sprague-Dawley rats pretreated with AFB1 (ip injection of 1 or 2 mg/kg body weight once weekly for 3 consecutive wk) and given a diet containing 50 ppm phenoclor DP6 for 11 days, the number of area of putative liver preneoplastic lesions were increased approximately four-fold as indicated by the number and gamma-glutamyl transpeptidase activity of enzyme-altered foci; this change was also accompanied by an increase in hepatic microsomal lipid peroxidation and a decrease in Se-glutathione peroxidase and superoxide dismutase activities. The results indicate that phenoclor DP6 exerts a promoting effect in AFB1-initiated rats.

• Authors: M A Pélissier, C Frayssinet, M Boisset, R Albrecht
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 30 Issue 2 Pg. 133-7 (Feb 1992) ISSN: 0278-6915 [Print] England
• PMID: 1348234 (Publication Type: Journal Article)

Chemical References

• phenoclor
• Aflatoxin B1
• Polychlorinated Biphenyls
• Glutathione Peroxidase
• Superoxide Dismutase
• gamma-Glutamyltransferase

Topics

• Aflatoxin B1 (toxicity)
• Animals
• Glutathione Peroxidase (metabolism)
• Lipid Peroxidation (drug effects)
• Liver (enzymology, pathology)
• Liver Neoplasms, Experimental (chemically induced, enzymology, pathology)
• Male
• Microsomes, Liver (metabolism)
• Polychlorinated Biphenyls (pharmacology, toxicity)
• Precancerous Conditions (chemically induced, enzymology, pathology)
• Rats
• Rats, Inbred Strains
• Superoxide Dismutase (metabolism)
• gamma-Glutamyltransferase (metabolism)