Abstract |
This investigation assessed the mechanisms of Tetrazepam action on spasticity using a battery of electromyographic methods. Thirty patients with post- stroke spastic hemiparesis treated with Tetrazepam took part in the investigation. A questionnaire for assessment of subjective improvement after treatment used a 5-point scale. The 5-point scales were used to assess muscle tone, muscle strength and tendon reflexes. A battery of electromyographic methods was used to analyse different mechanisms of spasticity: for alpha-motoneuron activity--the F-wave parameters; for gamma-motoneuron activity--the TA/H amplitude ratio; for presynaptic inhibition--the ratio of H-reflex maximal amplitudes before and after vibration on the Achilles tendon (Hvibr/Hmax); for common interneuron activity--the flexor reflex parameters. Our results revealed that Tetrazepam reduces tone in spastic muscles and has a slight effect on tendon hyperreflexia. It has no influence on muscle strength, Babinski sign and ankle clonus. Tetrazepam acts by decreasing motoneurone activity and increasing presynaptic inhibition.
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Authors | I Milanov |
Journal | Acta neurologica Belgica
(Acta Neurol Belg)
Vol. 92
Issue 1
Pg. 5-15
( 1992)
ISSN: 0300-9009 [Print] Italy |
PMID | 1347669
(Publication Type: Journal Article)
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Chemical References |
- Anti-Anxiety Agents
- Benzodiazepinones
- Benzodiazepines
- tetrazepam
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Topics |
- Aged
- Anti-Anxiety Agents
(therapeutic use)
- Benzodiazepines
- Benzodiazepinones
(pharmacology, therapeutic use)
- Electromyography
- Female
- H-Reflex
(drug effects)
- Hemiplegia
(drug therapy)
- Humans
- Male
- Middle Aged
- Motor Neurons
(drug effects)
- Muscle Contraction
(drug effects)
- Muscle Spasticity
(drug therapy)
- Muscle Tonus
(drug effects)
- Surveys and Questionnaires
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