Oximes and atropine in sarin poisoning.

Abstract

Three oximes, monoisonitrosoacetone (MINA), pyridine-2-aldoxime methiodide (PAM) and diacetylmonoxime (DAM), have been examined in combination with atropine as antidotes in sarin poisoning. When treatment was administered 15 min. before sarin, atropine enhanced the protective effect of MINA and DAM 2 to 3 times and of PAM 9 to 10 times in mice and rats. In mice, rats, and guinea-pigs, atropine increased by no more than 2 times the protective effect of all three oximes when given 30 sec. after sarin. Atropine given to monkeys 1 min. after sarin raised the LD50 approximately 3 times. When given in conjunction with MINA or DAM, the LD50 of sarin was raised 7 to 14 times.

• Authors: B M ASKEW
• Journal: British journal of pharmacology and chemotherapy (Br J Pharmacol Chemother) Vol. 12 Issue 3 Pg. 340-3 (Sep 1957) ISSN: 0366-0826 [Print] England
• PMID: 13460241 (Publication Type: Journal Article)

Chemical References

• Antidotes
• Cholinesterase Inhibitors
• Hydroxylamines
• Oximes
• Phosphates
• Pralidoxime Compounds
• diacetylmonoxime
• Atropine
• Sarin
• Diacetyl
• pralidoxime

Topics

• Animals
• Antidotes
• Atropine (pharmacology)
• Cholinesterase Inhibitors
• Diacetyl
• Drug-Related Side Effects and Adverse Reactions
• Guinea Pigs
• Hydroxylamines (pharmacology)
• Mice
• Organophosphate Poisoning
• Oximes
• Phosphates (poisoning)
• Pralidoxime Compounds
• Rats
• Sarin