[Modern trends in the treatment of ulcer disease (clinical study of nizatidine "Galitidine")].

Abstract

By an analysis of nizatidine vs ranitidine activity, the authors show a contemporary controlled approach to the treatment of ulcer disease. In a prospective, randomized, double-blind, parallel comparative, multicentric study, the treatment of duodenal ulcer was carried out in 120 patients with H2-receptor blockers, nizatidine and ranitidine. The treatment lasted one or two months with endoscopic control of the results. The recovery of the ulcer nische in patients who received nizatidine, 150 mg twice daily over a month, was achieved in 89.75% of the cases, while in those who at the same time received ranitidine twice daily ulcer was suppressed in 84.61% of the patients; in those who received Nizatidine, 300 mg once daily it was suppressed in 88.24% of the patients. Statistically, x2 = 2.177 with p > 0.3 which shows that there is no statistically significant differences between the groups although the first group shows the best results. Adverse effects of the drugs were not observed.

• Authors: D Dzambas, M Zivanović, J Majoros, Z Petrović, M Barjaktarović, L Hadnadev, Z Tomić, Z Mrda, D Damjanov
• Journal: Medicinski pregled (Med Pregl) Vol. 45 Issue 9-10 Pg. 353-8 ( 1992) ISSN: 0025-8105 [Print] Serbia
• Vernacular Title: Savremeni trendovi u lecenju ulkusne bolesti (Klinicko ispitivanje nizatidina "Galitidina").
• PMID: 1344473 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Ranitidine
• Nizatidine

Topics

• Adult
• Double-Blind Method
• Duodenal Ulcer (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Nizatidine (adverse effects, therapeutic use)
• Prospective Studies
• Ranitidine (adverse effects, therapeutic use)