[The effect of bretylium tosylate on ventricular arrhythmias in patients with acute myocardial infarction].

Abstract

Sixty three patients with the acute myocardial infarction, aged between 34 and 85 years, admitted to the Intensive Cardiological Care Unit during the first 12 hours following the infarction were randomly divided into two groups. Patients of group I (20 subjects) were treated with nitroglycerin and additional intravenous infusions of bretylium tosylate in the dose of 5 mg/kg administered every 6 hours for 48-72 hours. Patients of group II (33 subjects) were mainly treated with intravenous nitroglycerin. A type and incidence of the ventricular arrhythmias, conduction disorders in AV node, and hemodynamic complications were analysed during the first 72 hours. It was found that bretylium tosylate reduces the incidence of ventricular arrhythmias accompanying myocardial infarction but after 2-3 hours following its administration (p < 0.05). Therefore, bretylium tosylate should be administrated to patients with the acute myocardial infarction in combination with other rapidly acting anti-arrhythmic drug. Bretylium tosylate increases also the effectiveness of electric defibrillation in patients with ventricular fibrillation or ventricular tachyarrhythmia. No evidence of the effectiveness of bretylium tosylate on atrio-ventricular conduction and hemodynamic complications of myocardial infarction was found.

• Authors: M Kochmański, H Rdzanek, R J Zochowski
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) 1992 Oct 5-12 Vol. 47 Issue 40-41 Pg. 901-4 ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Wpływ tosylanu bretylium na komorowe zaburzenia rytmu u chorych w ostrej fazie świezego zawału serca.
• PMID: 1341893 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Bretylium Tosylate
• Nitroglycerin

Topics

• Adult
• Aged
• Aged, 80 and over
• Arrhythmias, Cardiac (epidemiology, etiology, prevention & control)
• Bretylium Tosylate (therapeutic use)
• Humans
• Incidence
• Middle Aged
• Myocardial Infarction (complications, drug therapy)
• Nitroglycerin (therapeutic use)