Serum soluble CD4, CD8 and IL-2R levels in adult acute myeloid leukemia in remission.

Abstract

We have measured the serum levels of soluble CD4, CD8 and IL-2R in 43 patients with AML in complete remission (AML-CR). The sCD8 levels of AML-CR patients (443.9 +/- 224.4 u/ml) were significantly high as compared to that of the normal controls (177.1 +/- 76.3 u/ml), p < 0.01. The sIL-2R levels of AML-CR patients were 715.0 +/- 646.3 u/ml, which significantly differed when compared to 322.1 +/- 65.7 u/ml for the normal controls, p < 0.01. However, the sCD4 levels of AML-CR patients were 9.6 +/- 4.7 u/ml, which did not differ from the 8.3 +/- 2.6 u/ml of the normal controls. The AML-CR patients showed significantly increased sCD8 and sIL-2R levels at all ranges during the remission from one to 188 months. The sCD8 levels and sIL-2R levels of the AML-CR patients showed a close correlation, p < 0.01. Further, the sCD8 levels and lymphokine activated killer cell cytotoxic activity showed a close correlation, p < 0.05. The presence of the activation of anti-tumor immunity may be related to the continuance of the remission in the AML-CR patients.

• Authors: Y Iizuka, M Aiso, T Ohshima, S Sawada, T Horie
• Journal: Medical oncology and tumor pharmacotherapy (Med Oncol Tumor Pharmacother) Vol. 9 Issue 2 Pg. 57-64 ( 1992) ISSN: 0736-0118 [Print] England
• PMID: 1341717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CD4 Antigens
• CD8 Antigens
• Interleukin-2
• Cytarabine
• Prednisolone
• Mercaptopurine
• Daunorubicin

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers (blood)
• CD4 Antigens (blood)
• CD8 Antigens (blood)
• Cytarabine (therapeutic use)
• Cytotoxicity, Immunologic (immunology)
• Daunorubicin (therapeutic use)
• Female
• Humans
• Immunophenotyping
• Interleukin-2 (blood)
• Killer Cells, Lymphokine-Activated (immunology)
• Killer Cells, Natural (immunology)
• Leukemia, Myeloid (drug therapy, immunology)
• Male
• Mercaptopurine (therapeutic use)
• Middle Aged
• Prednisolone (therapeutic use)
• Remission Induction