Abstract |
The gastric emptying of sodium citrate solution 0.25 mEq/ml was studied in rats with metabolic acidosis induced by orogastric infusion of 0.5 M ammonium chloride solution. Two control groups were used: one infused with 0.5 M sodium chloride and the other with water. The 3 solutions content was 2 ml/100 g weight of the animal. Six hours after the infusion, there was a moderate metabolic acidosis in the group with ammonium citrate. This 6 hour interval marked the beginning of the gastric emptying study. The test meal ( sodium citrate 0.25 mEq/ml) was utilized containing 6 mg% red fenol as a marker. The gastric emptying of sodium citrate was studied at 5, 10, 20 and 30 minutes after the infusion, and the results showed no differences between the 3 groups. The data suggest that the duodenal receptors to pH were more effective do determine the pattern of gastric response than the acidosis.
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Authors | E C Baracat, E F Collares |
Journal | Arquivos de gastroenterologia
(Arq Gastroenterol)
1992 Jul-Sep
Vol. 29
Issue 3
Pg. 101-5
ISSN: 0004-2803 [Print] Brazil |
Vernacular Title | Esvaziamento gástrico e acidose metabólica. III. Estudo da retenção gástrica de uma soluçao de citrato de sódio, utilizando um modelo experimental de acidose metabólica em ratos. |
PMID | 1339143
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Bicarbonates
- Citrates
- Ammonium Chloride
- Citric Acid
- Sodium Bicarbonate
- Sodium
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Topics |
- Acid-Base Equilibrium
(drug effects, physiology)
- Acidosis
(blood, chemically induced, metabolism)
- Ammonium Chloride
- Animals
- Bicarbonates
(blood)
- Citrates
(metabolism)
- Citric Acid
- Disease Models, Animal
- Female
- Gastric Emptying
- Rats
- Rats, Wistar
- Sodium
(blood)
- Sodium Bicarbonate
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