Osteoclastic superoxide generation: taking control of bone resorption using modulators of superoxide concentrations.

Abstract

We have examined the role of superoxide in bone resorption by stimulating defective superoxide production and bone resorption in patients with osteopetrosis and inhibiting superoxide production and bone resorption in murine calvarial explants. Interferon gamma treatment did stimulate superoxide generation and bone resorption in patients with osteopetrosis as evidenced by a reduction in bone volume and an increase in biochemical markers of bone resorption. Further, lowering the superoxide concentrations within calvarial osteoclasts using a scavenger, desferal manganese, decreased bone resorption. We conclude that superoxide generation by osteoclasts is necessary for normal osteoclastic function.

• Authors: L L Key Jr, W L Ries, H Glasscock, R Rodriguiz, H Jaffe
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 14 Issue 6 Pg. 295-8 ( 1992) ISSN: 0250-0868 [Print] Switzerland
• PMID: 1339119 (Publication Type: Journal Article)

Chemical References

• Free Radical Scavengers
• Organometallic Compounds
• Superoxides
• manganese desferioxamine
• Interferon-gamma
• Deferoxamine

Topics

• Animals
• Bone Resorption (metabolism, therapy)
• Culture Techniques
• Deferoxamine (analogs & derivatives, pharmacology)
• Free Radical Scavengers
• Humans
• Interferon-gamma (therapeutic use)
• Organometallic Compounds (pharmacology)
• Osteoclasts (metabolism)
• Osteopetrosis (metabolism)
• Rats
• Superoxides (metabolism)