Immunohistochemical identification of transforming growth factor-beta and its binding protein in human gastrointestinal carcinoma.

Abstract

We attempted to clarify the tissue localization of TGF-beta and latent TGF-beta binding protein (LTBP) in human gastrointestinal carcinomas by immunohistochemistry. The immunoreactivity for TGF-beta was observed in both carcinoma cells and stromal cells, particularly in diffuse-type gastric carcinoma. The immunoreactivity for LTBP was observed only in stromal cells. These results suggest that both carcinoma cells and stromal cells may produce TGF-beta, and that only stromal cells may produce LTBP in gastrointestinal carcinoma.

• Authors: T Mizoi, H Ohtani, S Matsuno, H Nagura
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 168 Issue 2 Pg. 271-3 (Oct 1992) ISSN: 0040-8727 [Print] Japan
• PMID: 1339102 (Publication Type: Journal Article)

Chemical References

• Receptors, Cell Surface
• Receptors, Transforming Growth Factor beta
• Transforming Growth Factor beta

Topics

• Gastrointestinal Neoplasms (chemistry)
• Humans
• Immunohistochemistry
• Receptors, Cell Surface (analysis)
• Receptors, Transforming Growth Factor beta
• Transforming Growth Factor beta (analysis)