[Effects of cytomegalovirus infection in pregnant women to fetuses: study with DNA-DNA hybridization method].

Abstract

DNA of cytomegalovirus (CMV) was examined in 131 placentae and 28 umbilical blood specimens by DNA-DNA hybridization. The result revealed that CMV DNA was detected in 4 of 50 placentae from abnormal fetuses (31 fetal deaths, 19 fetal deformities). 77 placentae from normal fetuses showed negative results. One of 2 cord blood samples from fetal deformities showed CMV DNA positive. 25 umbilical blood samples from normal term newborns showed negative. 4 placentae and 1 cord blood sample from premature infants showed negative results. The results indicate that CMV may play a great role in fetal death and fetal deformity through the infected maternal-fetal circulation.

• Authors: Y Y Ma
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 27 Issue 6 Pg. 355-8, 380 (Nov 1992) ISSN: 0529-567X [Print] China
• PMID: 1338629 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Viral

Topics

• Cytomegalovirus (isolation & purification)
• Cytomegalovirus Infections (microbiology, transmission)
• DNA, Viral (analysis)
• Female
• Fetal Blood (microbiology)
• Fetal Death (etiology)
• Fetus (abnormalities)
• Humans
• Maternal-Fetal Exchange
• Nucleic Acid Hybridization
• Placenta (microbiology)
• Pregnancy
• Pregnancy Complications, Infectious (microbiology)