[The cluster headache: a clinical model of immunologic receptor pathology?].

Abstract

It is well established that cluster headache shows impaired functions at their neuroimmunomodulatory system level. Defect in receptor expression for 5-HT, IL-1 and IL-2 have been found in these patients. Sumatriptan, a molecule with agonistic activity for 5-HT1D receptor, truncates cluster headache attacks in 74% of patients. Flow cytometric analysis of monocytes expressing 5-HT receptor in cluster headache patients showed different trends clearly correlated with the clinical response to sumatriptan. Our findings strongly support the concept that cluster headache patients who are non responders to sumatriptan could present a block in their 5-HT receptor possibly due to specific autoantibodies for this receptor site.

• Authors: M Giacovazzo, P Martelletti
• Journal: Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna (Ann Ital Med Int) 1992 Jul-Sep Vol. 7 Issue 3 Suppl Pg. 33S-37S ISSN: 0393-9340 [Print] Italy
• Vernacular Title: Cefalea a grappolo: modello clinico di immunorecettoropatia?
• PMID: 1338421 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Indoles
• Receptors, Immunologic
• Receptors, Serotonin
• Serotonin Receptor Agonists
• Sulfonamides
• Serotonin
• Sumatriptan
• Fluorescein-5-isothiocyanate

Topics

• Adult
• Cluster Headache (blood, drug therapy, etiology)
• Flow Cytometry
• Fluorescein-5-isothiocyanate
• Humans
• Indoles (therapeutic use)
• Male
• Monocytes (drug effects, physiology)
• Receptors, Immunologic (drug effects, physiology)
• Receptors, Serotonin (drug effects, physiology)
• Serotonin (blood)
• Serotonin Receptor Agonists (therapeutic use)
• Sulfonamides (therapeutic use)
• Sumatriptan