ACTH fragments reverse experimental haemorrhagic shock in rats.

Abstract

Hypovolemic shock was produced in rats by withdrawing about 50% of estimated total blood volume. Following mean arterial pressure stabilization in the range of 25-27 mmHg, the rats were given intravenous ACTH (1-4) (4-9) (4-10) (5-10) (1-10) in comparison with ACTH (1-24). The ACTH fragments, administered within 5 min after shock induction, promptly and dose-dependently improved mean arterial pressure and survival of rats; the ACTH (1-10) showed an activity similar to that of ACTH (1-24) whereas the other fragments were less active.

• Authors: G Coppi, A Falcone
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 18 Issue 5 Pg. 173-7 ( 1992) ISSN: 0378-6501 [Print] Switzerland
• PMID: 1337036 (Publication Type: Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (administration & dosage, pharmacology)
• Animals
• Blood Pressure (drug effects)
• Dose-Response Relationship, Drug
• Female
• Injections, Intravenous
• Rats
• Rats, Wistar
• Shock (drug therapy)