Late-onset homozygous protein C deficiency manifesting cerebral infarction as the first symptom at age 27.

Abstract

We report a 31-year-old female who had repeated thrombosis and was diagnosed as having congenital homozygous protein C deficiency based on decreased protein C antigen and activity, and the findings of family history. This patient had shown no symptom of thrombosis until the age of 27 years, when she had cerebral infarction as the first symptom. Low molecular weight heparin was useful for disseminated intravascular coagulation (DIC) that complicated protein C deficiency in this patient.

• Authors: K Deguchi, T Tsukada, E Iwasaki, H Wada, S Murashima, M Miyazaki, S Shirakawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 31 Issue 7 Pg. 922-5 (Jul 1992) ISSN: 0918-2918 [Print] Japan
• PMID: 1333307 (Publication Type: Case Reports, Journal Article)

Chemical References

• Heparin, Low-Molecular-Weight
• Protein C

Topics

• Adult
• Blood Coagulation Disorders (complications, genetics)
• Blood Coagulation Tests
• Cerebral Infarction (etiology)
• Disseminated Intravascular Coagulation (drug therapy, etiology)
• Female
• Heparin, Low-Molecular-Weight (therapeutic use)
• Humans
• Pedigree
• Protein C (genetics)
• Protein C Deficiency
• Recurrence
• Thrombosis (etiology)