[The therapy of severe forms of acute polyradiculoneuritis: corticosteroids, plasmapheresis or their combination?].

Abstract

A comparative examination was made of 62 patients with acute polyradiculoneuritis using hormonal therapy (HT), plasmapheresis (PA), their combination (HTPA) and maintenance therapy (MT). All the patients were distributed into 2 groups: group A (requiring artificial ventilation of the lungs--AVL) and group B (incapable of moving). Group A consisted of subgroups HT; HTPA; PA. Group B consisted of subgroups HT; MT; PA. The hormones (prednisolone or metipred) were applied in the doses 1 mg/kg according to the regressing scheme. The duration of AVL, the rate of the recovery of walking to the distance over 5 m both with and without support appeared in group A significantly higher (by 2-2.5 times), using PA alone. The analogous results were obtained in group B. At the same time, no significant differences were discovered between subgroups HT and HTPA (group A) and HT and MT (group B). It is recommended that MT be used in severe forms of acute polyradiculoneuritis in the stage of the increment of the neurological symptomatology. The volumes should not be less than 35-40 ml plasma/kg per operation and 120-160 ml plasma/kg per treatment course. The hormones may exert a "smoothing" action on the efficacy of PA.

• Authors: M A Piradov
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 92 Issue 3 Pg. 7-10 ( 1992) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Terapiia tiazhelykh form ostrogo poliradikulonevrita: kortikosteroidy, plazmaferez ili ikh sochetanie?
• PMID: 1332335 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones

Topics

• Acute Disease
• Adrenal Cortex Hormones (therapeutic use)
• Combined Modality Therapy
• Evaluation Studies as Topic
• Humans
• Plasmapheresis (methods)
• Polyradiculoneuropathy (complications, therapy)
• Remission Induction