Polyadenylic:polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection.

Abstract

Treatment of BALB/c mice with poly(A):poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A):poly(U)-induced protection of BALB/c mice is discussed.

• Authors: A Adams, M Mohrman, A G Johnson, A Morin, E Deschamps de Paillette
• Journal: The Journal of general virology (J Gen Virol) Vol. 73 ( Pt 9) Pg. 2409-13 (Sep 1992) ISSN: 0022-1317 [Print] England
• PMID: 1328496 (Publication Type: Journal Article)

Chemical References

• Poly A-U

Topics

• Animals
• Cytomegalovirus Infections (drug therapy, mortality, veterinary)
• Killer Cells, Natural (immunology)
• Mice
• Mice, Inbred BALB C
• Peritoneal Cavity (microbiology)
• Poly A-U (therapeutic use)
• Survival Analysis