| Abstract | In a multicenter study we selected 84 patients with fluctuating Parkinson's disease in order to evaluate the effects of controlled-release Sinemet 50/200 (=CR) versus standard Sinemet 25/100 (=STD) in an open-label 8-week titration period, followed by a double-blind, double-dummy 24-week treatment period. In contrast with previous double-blind studies, the efficacy of Sinemet CR proved to be significantly superior to that of Sinemet-STD according to NYUPDS and NUDS rating scales. This higher efficacy of Sinemet CR was not achieved at the expense of safety and/or tolerability. Actual total daily levodopa dosage in patients treated with Sinemet CR was increased by 33%; however, the plasma level of this dosage is calculated to be similar to that of the previous dosage of Sinemet-STD (bio-availability of Sinemet CR is 71%). Mean numbers of daily doses, off-hours, and off-periods were decreased significantly during Sinemet CR treatment. Although all other variables suggest that the number of on-hours had to be increased, statistical significance could not be reached in this respect. |
| Authors | E C Wolters, M W Horstink, R A Roos, E N Jansen
(Affiliation: Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.)
|
| Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 94
Issue 3
Pg. 205-11
( 1992)
ISSN: 0303-8467 NETHERLANDS |
| PMID | 1327609
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
| Chemical References |
- Antiparkinson Agents
- Drug Combinations
- Levodopa
- Carbidopa
- Sinemet
|
| Topics |
- Antiparkinson Agents
(administration & dosage, adverse effects, pharmacokinetics)
- Carbidopa
(administration & dosage, adverse effects, pharmacokinetics)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Drug Combinations
- Female
- Humans
- Levodopa
(administration & dosage, adverse effects, pharmacokinetics)
- Male
- Middle Aged
- Neurologic Examination
(drug effects)
- Parkinson Disease
(blood, diagnosis, drug therapy)
- Patient Satisfaction
- Sleep Stages
(drug effects)
|
