Abstract |
Preconditioning the brain with sublethal ischemia induces tolerance to subsequent ischemic insult. Using [3H] quinuclidinyl benzilate (QNB), [3H] MK 801, [3H]cyclohexyladenosine, [3H] muscimol, and [3H]PN200-110, we investigated the alterations in neurotransmitter receptor and calcium channel binding in the gerbil hippocampus following ischemia with or without preconditioning. Two-minute forebrain ischemia, which produced no neuronal damage, resulted in no alterations in binding except for a slight reduction in [3H]QNB binding in the CA1 subfield. Three-minute ischemia destroyed the majority of CA1 pyramidal cells and caused, in CA1, reductions in binding of all ligands used. Preconditioning with 2-min ischemia followed by 4 days of reperfusion protected against CA1 neuronal damage and prevented the reductions in binding although [3H]QNB and [3H]PN200-110 binding transiently decreased in the early reperfusion period, suggesting down-regulation. Thus, preconditioning protects against damage to the neurotransmission system as well as histopathological neuronal death.
|
Authors | H Kato, T Araki, K Kogure |
Journal | Brain research bulletin
(Brain Res Bull)
1992 Sep-Oct
Vol. 29
Issue 3-4
Pg. 395-400
ISSN: 0361-9230 [Print] United States |
PMID | 1327423
(Publication Type: Journal Article)
|
Chemical References |
- Receptors, Neurotransmitter
- Muscimol
- N(6)-cyclohexyladenosine
- Quinuclidinyl Benzilate
- Dizocilpine Maleate
- Adenosine
- Isradipine
|
Topics |
- Adenosine
(analogs & derivatives, metabolism)
- Animals
- Autoradiography
- Brain Ischemia
(metabolism)
- Conditioning, Psychological
(physiology)
- Dizocilpine Maleate
(metabolism)
- Down-Regulation
- Gerbillinae
- Hippocampus
(anatomy & histology, metabolism)
- Isradipine
(metabolism)
- Male
- Muscimol
(metabolism)
- Quinuclidinyl Benzilate
(metabolism)
- Receptors, Neurotransmitter
(metabolism)
|