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Preserved neurotransmitter receptor binding following ischemia in preconditioned gerbil brain.

Abstract
Preconditioning the brain with sublethal ischemia induces tolerance to subsequent ischemic insult. Using [3H]quinuclidinyl benzilate (QNB), [3H]MK 801, [3H]cyclohexyladenosine, [3H]muscimol, and [3H]PN200-110, we investigated the alterations in neurotransmitter receptor and calcium channel binding in the gerbil hippocampus following ischemia with or without preconditioning. Two-minute forebrain ischemia, which produced no neuronal damage, resulted in no alterations in binding except for a slight reduction in [3H]QNB binding in the CA1 subfield. Three-minute ischemia destroyed the majority of CA1 pyramidal cells and caused, in CA1, reductions in binding of all ligands used. Preconditioning with 2-min ischemia followed by 4 days of reperfusion protected against CA1 neuronal damage and prevented the reductions in binding although [3H]QNB and [3H]PN200-110 binding transiently decreased in the early reperfusion period, suggesting down-regulation. Thus, preconditioning protects against damage to the neurotransmission system as well as histopathological neuronal death.
AuthorsH Kato, T Araki, K Kogure
JournalBrain research bulletin (Brain Res Bull) 1992 Sep-Oct Vol. 29 Issue 3-4 Pg. 395-400 ISSN: 0361-9230 [Print] United States
PMID1327423 (Publication Type: Journal Article)
Chemical References
  • Receptors, Neurotransmitter
  • Muscimol
  • N(6)-cyclohexyladenosine
  • Quinuclidinyl Benzilate
  • Dizocilpine Maleate
  • Adenosine
  • Isradipine
Topics
  • Adenosine (analogs & derivatives, metabolism)
  • Animals
  • Autoradiography
  • Brain Ischemia (metabolism)
  • Conditioning, Psychological (physiology)
  • Dizocilpine Maleate (metabolism)
  • Down-Regulation
  • Gerbillinae
  • Hippocampus (anatomy & histology, metabolism)
  • Isradipine (metabolism)
  • Male
  • Muscimol (metabolism)
  • Quinuclidinyl Benzilate (metabolism)
  • Receptors, Neurotransmitter (metabolism)

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