Abstract |
The effect of a novel, highly potent and selective kappa-opioid receptor agonist CI-977 upon ischaemic brain damage and brain swelling has been examined in a rat model of focal cerebral ischaemia. Focal ischaemia was produced by the permanent occlusion of the left middle cerebral artery (MCA) during a brief period of halothane anaesthesia. The animals were sacrificed 24 h after MCA occlusion and the amount of ischaemic brain damage and swelling was assessed in coronal sections at 8 predetermined stereotactic planes. Treatment with CI-977 (0.03, 0.3 or 3 mg/kg), initiated 30 min prior to MCA occlusion (and at multiple times thereafter) produced dose-dependent reductions in the volumes of infarction and of brain swelling, with the most marked reductions being noted with CI-977 (0.3 mg/kg) in both infarction (reduced by 38% from controls; P less than 0.02) and swelling (reduced by 31%; P less than 0.002). There was an excellent correlation between the volume of brain swelling and ischaemic damage which was similar with saline-treated and CI-977-treated animals (overall correlation coefficient r = 0.896). These results indicate that CI-977 is effective in reducing infarction in a model of focal cerebral ischaemia, and that the reduction in brain swelling occurs in parallel with the reduction in ischaemic damage.
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Authors | K Kusumoto, K B Mackay, J McCulloch |
Journal | Brain research
(Brain Res)
Vol. 576
Issue 1
Pg. 147-51
(Mar 27 1992)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 1325235
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzofurans
- Pyrrolidines
- Receptors, Opioid
- Receptors, Opioid, kappa
- enadoline
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Topics |
- Animals
- Benzofurans
(pharmacology)
- Brain Edema
(prevention & control)
- Cerebral Infarction
(prevention & control)
- Disease Models, Animal
- Ischemic Attack, Transient
(pathology, physiopathology)
- Male
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Receptors, Opioid
(drug effects, physiology)
- Receptors, Opioid, kappa
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