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Production of chromogranin A and B derived peptides in human small cell lung carcinoma cell lines.

Abstract
Production of chromogranin (Cg)A and B derived peptides [pancreastatin (PST), GAWK, CCB] was studied using human lung carcinoma derived cell lines. PST-like immunoreactivity (LI) was detected in the culture medium in 3 of 6 small cell lung carcinoma (SCLC) cell lines, while GAWK- and CCB-LIs were detected in 5 of 6 and all the 6 SCLC cell lines, respectively. CCB-LI was produced in large amounts in SCLC cell lines as compared to PST- and GAWK-LIs. In non-SCLC cell lines, on the other hand, PST- and GAWK-LIs were not detected. CCB-LI was detected in 1 of 7 non-SCLC cell lines, but not detected in the remainder. PST, GAWK and CCB-LIs, secreted by these cell lines, consisted of several peaks, and these peaks were different among cell lines. This suggests that processing of CgA and B is different in the cell lines. Production of CgA and B derived peptides seems to be a characteristic feature of SCLC, and among them, CCB LI may be a useful marker for SCLC.
AuthorsH Iguchi, S Bannai, N Takanashi, Y Tsukada
JournalEuropean journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 28A Issue 8-9 Pg. 1458-62 ( 1992) ISSN: 0959-8049 [Print] England
PMID1325178 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CHGA protein, human
  • Chromogranin A
  • Chromogranins
  • Culture Media
  • Neoplasm Proteins
  • Peptide Fragments
Topics
  • Carcinoma, Small Cell (metabolism)
  • Chromatography, Gel
  • Chromogranin A
  • Chromogranins (metabolism)
  • Culture Media
  • Humans
  • Lung Neoplasms (metabolism)
  • Neoplasm Proteins (biosynthesis)
  • Peptide Biosynthesis
  • Peptide Fragments (biosynthesis)
  • Tumor Cells, Cultured (metabolism)

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