Abstract |
The clinical characteristics and the results of mineral fibre and cytogenetic analyses were coordinated prospectively for 41 patients with confirmed malignant pleural mesothelioma. A correlation was found between high total fibre concentration, and partial or total loss of chromosomes 1, 4 and 9 and chromosomal rearrangements involving a breakpoint at 1p11-p22. There was also a correlation between crocidolite/ amosite as the main fibre type and partial or total loss of chromosomes 1, 3 and 4 and chromosomal rearrangements involving del (3p). Positive prognostic factors were female gender, low total fibre concentration (less than 10(6) fibres per g dried lung tissue), anthophyllite as the main fibre type and normal chromosome 7. In addition, we found 4 patients with malignant mesothelioma who had been exposed mainly to anthophyllite fibres (total lung fibre concentrations of 1.2, 0.4, 0.2 and 0.1 x 10(6) fibres per g dried lung tissue). This would seem to indicate that there may be a carcinogenic role for anthophyllite.
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Authors | L Tammilehto, T Tuomi, M Tiainen, J Rautonen, S Knuutila, S Pyrhönen, K Mattson |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 28A
Issue 8-9
Pg. 1373-9
( 1992)
ISSN: 0959-8049 [Print] England |
PMID | 1325175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Asbestos, Amphibole
- Asbestos, Crocidolite
- Asbestos, Amosite
- Asbestos
- anthophyllite
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Asbestos
(adverse effects)
- Asbestos, Amosite
- Asbestos, Amphibole
- Asbestos, Crocidolite
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 7
- Female
- Humans
- Karyotyping
- Male
- Mesothelioma
(genetics, mortality, pathology)
- Middle Aged
- Pleural Neoplasms
(genetics, mortality, pathology)
- Prognosis
- Sex Factors
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