HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sympathetic preganglionic neurons projecting to the adrenal medulla and aorticorenal ganglion in the rabbit.

Abstract
The distribution of sympathetic preganglionic neurons (SPN) projecting to the adrenal medulla and the aorticorenal ganglion in the rabbit was studied using a dual retrograde transport technique. The B subunit of cholera toxin (CTB) was injected into the left adrenal medulla and wheatgerm agglutinin-apo-horseradish peroxidase-7 nm gold (WGA-apo-HRP-gold) was injected into the left aorticorenal ganglion. Retrogradely transported CTB was detected by immunohistochemistry, while gold particles were detected by silver intensification. SPN projecting to the adrenal medulla were observed in segments T2-L2 of the spinal cord in 5 rabbits, with the majority of cells within segments T6-T11 (79%). SPN projecting to the aorticorenal ganglion were seen in segments T2-L1 of the spinal cord in 5 rabbits, with the greatest number of the cells within T6-T11 (81%). Only a small number of doubly labelled cells (1%) were found in two rabbits. The results suggest that despite their similar segmental distribution SPN projecting to the adrenal medulla or the aorticorenal ganglion belong to separate populations and few, if any, individual SPN have axonal projections to both locations.
AuthorsI Jensen, P Pilowsky, I Llewellyn-Smith, J Minson, J Chalmers
JournalBrain research (Brain Res) Vol. 586 Issue 1 Pg. 125-9 (Jul 17 1992) ISSN: 0006-8993 [Print] Netherlands
PMID1324777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins
  • wheat germ agglutinin-apohorseradish peroxidase conjugate gold complex
  • Cholera Toxin
  • Horseradish Peroxidase
Topics
  • Adrenal Medulla (physiology)
  • Animals
  • Aorta (innervation)
  • Cholera Toxin
  • Ganglia (physiology)
  • Horseradish Peroxidase
  • Kidney (innervation)
  • Male
  • Neurons (physiology)
  • Rabbits
  • Sympathetic Nervous System (cytology, physiology)
  • Synaptic Transmission
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
  • Wheat Germ Agglutinins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: