Itraconazole in the treatment of cryptococcal meningitis.

Abstract

The results of an open study of the efficacy of oral itraconazole therapy in 8 patients with cryptococcal meningitis are reported. Therapy is monitored by clinical response with culture, indian ink stain and cryptococcal antigen testing of CSF. Four (50%) of eight patients were cured, two (25%) had partial response, and two (25%) failed. One patient had a relapse but responded to retreatment. No toxicity was observed. Itraconazole is, therefore, suggested as a new treatment for cryptococcal meningitis.

• Authors: V Chotmongkol, S Jitpimolmard
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 75 Issue 2 Pg. 85-8 (Feb 1992) ISSN: 0125-2208 [Print] Thailand
• PMID: 1322948 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antifungal Agents
• Itraconazole
• Ketoconazole

Topics

• Adolescent
• Adult
• Antifungal Agents (administration & dosage, therapeutic use)
• Cerebrospinal Fluid (microbiology)
• Female
• Humans
• Itraconazole
• Ketoconazole (administration & dosage, analogs & derivatives, therapeutic use)
• Male
• Meningitis, Cryptococcal (blood, cerebrospinal fluid, drug therapy)