Abstract |
The effects of new aryl- sydnones: 3-[4-X-3-nitrophenyl]-1,2,3-oxadiazolium-5-olates, where X = Cl (SYD-1); pyrrolidino (SYD-2); piperidino (SYD-3) and morpholino (SYD-4) on the survival of mice bearing Sarcoma 180, Ehrlich carcinoma, B10MCII ( Fibrous histiocytoma) and L1210 leukemia ascitic tumours, on the proliferation of cultured tumour cells and on the synthesis of DNA in L1210 leukemia were determined. SYD-1 and SYD-2 in vivo significantly enhanced the survival of S180, Ehrilich and B10MCII tumour-bearing mice. Furthermore, SYD-2 showed significant activity against L1210. SYD-3 and SYD-4 did not show antitumour activity. SYD-1, in vitro was the most cytotoxic against all the above tumour cells. All of the drugs tested inhibited thymidine uptake by L1210 cells, SYD-4 being the least active.
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Authors | N Grynberg, R Gomes, T Shinzato, A Echevarria, J Miller |
Journal | Anticancer research
(Anticancer Res)
1992 May-Jun
Vol. 12
Issue 3
Pg. 1025-8
ISSN: 0250-7005 [Print] Greece |
PMID | 1320354
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Sydnones
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology, therapeutic use)
- Blood Cell Count
(drug effects)
- Carcinoma, Ehrlich Tumor
(drug therapy)
- Drug Evaluation, Preclinical
- Histiocytoma, Benign Fibrous
(drug therapy)
- Leukemia L1210
(drug therapy)
- Male
- Mice
- Mice, Inbred DBA
- Mice, Inbred Strains
- Molecular Structure
- Neoplasms, Experimental
(drug therapy)
- Sarcoma 180
(drug therapy)
- Structure-Activity Relationship
- Sydnones
(chemistry, pharmacology, therapeutic use)
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