Abstract |
Retinoic acid causes a range of embryonic defects, including craniofacial abnormalities, in both birds and mammals and is believed to have a number of roles in normal development. We have previously shown that the distribution of retinoic acid receptor-beta ( RAR-beta) transcripts is spatially restricted within the neural-crest-derived upper beak primordia of the chick embryo. We have now used in situ hybridisation to trace the distribution of RAR-beta transcripts during the migration of cranial neural crest cells and during formation of these primordia. RAR-beta transcripts were present in a subset of migrating neural-crest-derived cells in the head of the stage 10 embryo. These cells were situated in pathways followed by cells that migrate from the neural crest overlying the posterior prosencephalic/anterior mesencephalic region of the developing brain. Cells containing RAR-beta transcripts accumulated around the developing eyes and in the regions of the ventral head from which the upper beak primordia later develop. We mapped the distribution of RAR-beta transcripts as the facial primordia were forming, with particular reference to the development of the maxillary primordia. We found that these form in a region of the ventral head that includes the boundary between regions of high and low levels of RAR-beta transcripts. The boundary between these two groups of cells persisted as the maxillary primordia developed.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | A Rowe, J M Richman, P M Brickell |
Journal | Development (Cambridge, England)
(Development)
Vol. 114
Issue 3
Pg. 805-13
(Mar 1992)
ISSN: 0950-1991 [Print] England |
PMID | 1319895
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- Receptors, Retinoic Acid
- Tretinoin
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Topics |
- Animals
- Carrier Proteins
(physiology)
- Cell Movement
(physiology)
- Chick Embryo
- Face
(embryology)
- Maxillofacial Development
(genetics)
- Molecular Probe Techniques
- Morphogenesis
(genetics)
- Neural Crest
(physiology)
- Receptors, Retinoic Acid
- Tretinoin
(metabolism)
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