Alpha-1 anti-trypsin and CD30 expression occur in parallel in activated T cells.

Abstract

We have performed an immunohistochemical study of immunoblastic T cell lymphoma and enteropathy-associated T cell lymphoma for alpha-1 anti-trypsin and CD30. Cytoplasmic staining for alpha 1 anti-trypsin is present in the malignant cells in both types of T cell neoplasm which also express CD30, a marker of lymphoid activation. Peripheral blood T lymphocytes on stimulation with mitogen also show granular cytoplasmic expression of alpha 1 anti-trypsin. Time course studies show that this parallels the expression of CD30. Alpha 1 anti-trypsin expression appears therefore to be associated with activation in T cells. Further studies of sub-fractionated T lymphocytes in vitro suggest that the expression of alpha 1 anti-trypsin on activation is not restricted to an individual lymphocyte subset.

• Authors: M S Bashir, D B Jones, D H Wright
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 88 Issue 3 Pg. 543-7 (Jun 1992) ISSN: 0009-9104 [Print] England
• PMID: 1318806 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Antigens, Neoplasm
• Ki-1 Antigen
• Ki-67 Antigen
• Nuclear Proteins
• alpha 1-Antitrypsin

Topics

• Antigens, CD (biosynthesis)
• Antigens, Neoplasm (biosynthesis)
• Gene Expression
• Humans
• Immunophenotyping
• Ki-1 Antigen
• Ki-67 Antigen
• Lymphocyte Activation (physiology)
• Lymphoma, T-Cell (immunology)
• Nuclear Proteins (biosynthesis)
• T-Lymphocytes (metabolism)
• alpha 1-Antitrypsin (biosynthesis)