A new
penicillin salt-
N,N'-dibenzylethylenediamine dipenicillin G (
Bicillin)(a)-was given, in single
injections of 2,500,000 units, to 196 patients with early infectious
syphilis. The seronegativity rates after three months were 65% for
primary syphilis cases and 25% for
secondary syphilis patients; after six months, the rates were 80% and 60%, respectively. At the end of the 21-month observation period, satisfactory results were recorded in 96.6%-100.0% of the
primary syphilis patients, and in 92%-95% of those treated for
secondary syphilis. The respective cumulative re-treatment rates were 3.4% and 4.1%.The results of the
secondary syphilis treatment were then compared with those obtained with single-injection schedules of 2,400,000 and 4,800,000 units of
procaine penicillin G in oil with 2%
aluminium monostearate (PAM). The cumulative re-treatment rates 21 months
after treatment were:
Bicillin, 4.1%; PAM (2.4 million units), 14.2%; and PAM (4.8 million units), 5.1%. It would thus appear that a single injection of 2,500,000 units of
Bicillin is as effective as one of 4,800,000 units of PAM.