Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung.

Abstract

BACKGROUND:

The level of expression of H/Le(y)/Le(b) antigens is high in various histologic types of lung cancer, a feature that may be related to deletion of A and B blood-group antigens. We evaluated the possibility that expression of this antigen, which can be defined by the monoclonal antibody MIA-15-5, might be of prognostic value, as suggested by our previous observation that MIA-15-5 inhibits tumor-cell motility and metastasis.

METHODS:

We used MIA-15-5 to stain tissue sections from 149 patients with primary lung cancer whose clinico-pathological histories were well documented. The survival curves for patients whose tumors stained positively were compared with the curves for those whose tumors stained negatively. Multivariate analyses were performed with a Cox proportional-hazards regression model.

RESULTS:

Among the 149 patients studied, five-year survival in the 91 patients with MIA-positive tumors was significantly lower than survival in the 58 with MIA-negative tumors (20.9 percent vs. 58.6 percent, P less than 0.001). Among the 67 patients with squamous-cell carcinoma, the rates also differed significantly (10.5 percent vs. 62.1 percent, P less than 0.001). The difference in survival between patients with MIA-positive tumors and those with MIA-negative tumors was significant among patients with blood groups A and AB (P less than 0.001), but not among those with blood group B or O (P = 0.071 and 0.068, respectively). Multivariate analysis with the Cox regression model indicated that positivity best correlated with five-year mortality, followed by lymph-node status (N stage) and tumor size status (T stage), whereas sex, age, and blood group did not correlate with mortality.

CONCLUSIONS:

Positivity for MIA (i.e., immunohistologic staining by MIA-15-5, which defines H/Le(y)/Le(b) antigens) is inversely correlated with survival among patients with primary lung cancer and may be of prognostic value.

• Authors: M Miyake, T Taki, S Hitomi, S Hakomori
• Journal: The New England journal of medicine (N Engl J Med) Vol. 327 Issue 1 Pg. 14-8 (Jul 02 1992) ISSN: 0028-4793 [Print] United States
• PMID: 1317941 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• ABO Blood-Group System
• Antibodies, Monoclonal
• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Lewis Blood Group Antigens

Topics

• ABO Blood-Group System (analysis)
• Adenocarcinoma (genetics, mortality)
• Antibodies, Monoclonal
• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Carcinoma (mortality)
• Carcinoma, Small Cell (genetics, mortality)
• Carcinoma, Squamous Cell (genetics, mortality)
• Cell Movement
• Female
• Humans
• Immunohistochemistry
• Lewis Blood Group Antigens (analysis)
• Lung Neoplasms (genetics, mortality)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Survival Rate