Use of ameroid constrictors in the development of renin-dependent hypertension in dogs.

Abstract

We describe methods for using ameroid constrictors to develop renin-dependent hypertension in dogs. A vascular-access-port was implanted in each dog and mean arterial blood pressure was monitored. Via a small flank incision, an ameroid constrictor was placed on the left renal artery and mean arterial blood pressure, plasma renin activity, and the response to angiotensin-converting enzyme inhibition measured during the subsequent 4 weeks. Placement of the constrictor on the left renal artery resulted in a significant increase in plasma renin activity which was accompanied by a significant hypertension (blood pressure greater than 140 mmHg). The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.). The results of this study indicate that ameroid constrictors provide a reliable method for establishing renin-dependent hypertension in dogs.

• Authors: D P Brooks, T A Fredrickson
• Journal: Laboratory animal science (Lab Anim Sci) Vol. 42 Issue 1 Pg. 67-9 (Feb 1992) ISSN: 0023-6764 [Print] United States
• PMID: 1316513 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Caseins
• Hydrogels
• ameroid
• Renin

Topics

• Animals
• Biocompatible Materials (adverse effects)
• Blood Pressure (drug effects)
• Caseins
• Constriction
• Disease Models, Animal
• Dogs
• Heart Rate (drug effects)
• Hydrogels
• Hypertension, Renal (blood, etiology)
• Male
• Renal Artery (surgery)
• Renin (blood, drug effects, physiology)