Abstract | OBJECTIVE: DESIGN: Potentiation of skin reaction to i.d. injections of bradykinin and histamine was evaluated in guinea pigs in the presence and absence of the drug (placebo, Ro 42-5892 or cilazapril). The elimination rate of radioactive bradykinin in blood was measured in other groups of guinea pigs treated with the same drugs. Maximal effective doses of each drug were used. METHODS: Measurements of erythema area induced by bradykinin and histamine injection were performed using a digital planimeter. Radioactive bradykinin was measured in blood by high-performance liquid chromatography and followed over 40 min. RESULTS: CONCLUSION:
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Authors | M Véniant, J P Clozel, W Fischli |
Journal | Journal of hypertension
(J Hypertens)
Vol. 10
Issue 2
Pg. 155-60
(Feb 1992)
ISSN: 0263-6352 [Print] England |
PMID | 1313478
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Imidazoles
- Pyridazines
- Cilazapril
- Renin
- remikiren
- Bradykinin
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects, pharmacology)
- Animals
- Antihypertensive Agents
(pharmacology)
- Bradykinin
(drug effects)
- Chromatography, High Pressure Liquid
- Cilazapril
- Drug Eruptions
(etiology)
- Drug Synergism
- Erythema
(chemically induced)
- Guinea Pigs
- Imidazoles
- Pyridazines
(adverse effects, pharmacology)
- Renin
(antagonists & inhibitors, pharmacology)
- Renin-Angiotensin System
(drug effects)
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