| Abstract | Sixteen of 110 hemodialysis (HD) patients fulfilling criteria of non-A, non B hepatitis (NANBH), i.e. alanine aminotransferase (ALT) greater than 50 U/ml in the absence of both serologic markers for acute HBV and HAV infections and clinical evidence of another cause of hepatitis, were tested for the presence of antibodies against hepatitis C virus (anti-HCV) by enzyme immunoassay (Ortho, Diagnostics). All (100%) were anti-HCV-positive. There were 5 patients with a monophasic (M) rise pattern (1 or 2 ALT rises), and 11 cases demonstrated a polyphasic (P) rise elevation pattern (more than 2). The mean ALT value of the M group was 202.3 +/- 209 U/ml and that of the P group was 116.6 +/- 39.1 U/ml. The patients received a mean of 19.1 +/- 16.2 units of packed red cells during the follow-up period (69.9 months). Only 1 patient received no blood transfusion. Six patients had a past HBV infection and 3 became HIV-infected in the course of this study. The high rate of infection of hemodialysis patients with hepatitis C virus in our setting points to the need for improved control measures. |
| Authors | C F Yoshida, C Takahashi, A M Gaspar, H G Schatzmayr, F Ruzany
(Affiliation: Department of Virology, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.)
|
| Journal | Nephron
(Nephron)
Vol. 60
Issue 2
Pg. 150-3
( 1992)
ISSN: 0028-2766 SWITZERLAND |
| PMID | 1313155
(Publication Type: Journal Article)
|
| Chemical References |
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| Topics |
- Adult
- Blotting, Western
- Enzyme-Linked Immunosorbent Assay
- Female
- Hepacivirus
(immunology)
- Hepatitis Antibodies
(analysis)
- Hepatitis C
(transmission)
- Humans
- Kidney Failure, Chronic
(complications, microbiology, therapy)
- Male
- Middle Aged
- Prevalence
- Renal Dialysis
(adverse effects)
|
