The effect of 3 mouthrinses on plaque and gingivitis development.

Abstract

The aim of this study was to evaluate the effect of 3 mouthrinses, Listerine Antiseptic (thymol), Peridex (chlorhexidine), Perimed (povidone iodine and hydrogen peroxide), and a placebo (water) on the development of dental plaque and gingivitis, when used as the only oral hygiene procedure for 14 days. 71 subjects were entered into a randomized, double-blind study. At the baseline examination, papillary bleeding score (PBS), and plaque index (PI) were registered, after which subjects received supragingival prophylaxis and were assigned to 1 of 4 study cells. Subjects were asked to refrain from all oral hygiene procedures except for the supervised 14-day 2 x daily rinsing with the assigned preparation. At day 14, the same clinical parameters were again registered. Statistical analysis was performed by a one-way analysis of variance (ANOVA) to compare the 4 groups, followed by Duncan's multiple range test to determine specific group differences. At baseline, average PBS and PI scores were similar for all 4 groups. After 14 days, the average PBS for Peridex and Perimed was significantly lower than for Listerine Antiseptic and water. The frequency of interdental units with a PBS greater than 2 was significantly lower for Peridex and Perimed than for Listerine Antiseptic and water. We concluded that both Peridex and Perimed were effective in reducing plaque and gingivitis when used as a 2 x daily mouthrinse by subjects refraining from other oral hygiene procedures. In vitro, a synergistic effect was assumed when inhibition was achieved with Perimed at the same or greater dilution than was achieved with povidone-iodine alone.

• Authors: J Maruniak, W B Clark, C B Walker, I Magnusson, R G Marks, M Taylor, B Clouser
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 19 Issue 1 Pg. 19-23 (Jan 1992) ISSN: 0303-6979 [Print] United States
• PMID: 1310096 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Drug Combinations
• Mouthwashes
• Placebos
• Salicylates
• Terpenes
• Water
• Perimed
• Listerine
• Iodine
• Hydrogen Peroxide
• Povidone
• chlorhexidine gluconate
• Chlorhexidine

Topics

• Actinomyces viscosus (drug effects)
• Adolescent
• Aggregatibacter actinomycetemcomitans (drug effects)
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Bacteroides (drug effects)
• Capnocytophaga (drug effects)
• Chlorhexidine (administration & dosage, analogs & derivatives, therapeutic use)
• Dental Plaque (prevention & control)
• Double-Blind Method
• Drug Combinations
• Female
• Fusobacterium nucleatum (drug effects)
• Gingivitis (prevention & control)
• Humans
• Hydrogen Peroxide (administration & dosage, therapeutic use)
• Iodine (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Mouthwashes (administration & dosage, therapeutic use)
• Placebos
• Porphyromonas gingivalis (drug effects)
• Povidone (administration & dosage, therapeutic use)
• Salicylates (administration & dosage, therapeutic use)
• Terpenes (administration & dosage, therapeutic use)
• Water