[Hypoglycemic activity of bicyclic diterpenoids of the clerodane series as compared to adebit and maninil].

Abstract

Biocyclic diterpenoids--salvin, salvicin and salvifolin, administered per os to rats at a dose of 50 mg/kg show marked hypoglycemic activity in intact animals as well as in animals with experimental hyperglycemia developing against a background of GTT (3000 mg/kg intraperitoneally) or alloxan (150 mg/kg subcutaneously). They are superior to adebit but inferior to maninil. Prophylactic and therapeutic administration of these compounds ensure the preservation of islet beta-cells in animals with alloxan diabetes.

• Authors: M A Tashmukhamedova, O A Mukhina, V N Syrov, Z A Khushbaktova, S P Katkova, M I Kosovskiĭ
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1992 Jan-Feb Vol. 38 Issue 1 Pg. 48-50 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Izuchenie gipoglikemicheskoĭ aktivnosti bitsiklicheskikh diterpenoidov klerodanovogo riada v sravnenii s adebitom i maninilom.
• PMID: 1308597 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Abietanes
• Bridged Bicyclo Compounds
• Diterpenes
• Hypoglycemic Agents
• Plant Extracts
• salvicin
• salvipholin
• Carnosine
• salvin
• Glyburide
• Buformin

Topics

• Abietanes
• Administration, Oral
• Animals
• Bridged Bicyclo Compounds (therapeutic use)
• Buformin (therapeutic use)
• Carnosine (analogs & derivatives, therapeutic use)
• Diabetes Mellitus, Experimental (drug therapy)
• Diterpenes (pharmacology, therapeutic use)
• Glyburide (therapeutic use)
• Hypoglycemic Agents (therapeutic use)
• Male
• Plant Extracts (therapeutic use)
• Rats