Abstract |
Biocyclic diterpenoids-- salvin, salvicin and salvifolin, administered per os to rats at a dose of 50 mg/kg show marked hypoglycemic activity in intact animals as well as in animals with experimental hyperglycemia developing against a background of GTT (3000 mg/kg intraperitoneally) or alloxan (150 mg/kg subcutaneously). They are superior to adebit but inferior to maninil. Prophylactic and therapeutic administration of these compounds ensure the preservation of islet beta-cells in animals with alloxan diabetes.
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Authors | M A Tashmukhamedova, O A Mukhina, V N Syrov, Z A Khushbaktova, S P Katkova, M I Kosovskiĭ |
Journal | Problemy endokrinologii
(Probl Endokrinol (Mosk))
1992 Jan-Feb
Vol. 38
Issue 1
Pg. 48-50
ISSN: 0375-9660 [Print] Russia (Federation) |
Vernacular Title | Izuchenie gipoglikemicheskoĭ aktivnosti bitsiklicheskikh diterpenoidov klerodanovogo riada v sravnenii s adebitom i maninilom. |
PMID | 1308597
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Abietanes
- Bridged Bicyclo Compounds
- Diterpenes
- Hypoglycemic Agents
- Plant Extracts
- salvicin
- salvipholin
- Carnosine
- salvin
- Glyburide
- Buformin
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Topics |
- Abietanes
- Administration, Oral
- Animals
- Bridged Bicyclo Compounds
(therapeutic use)
- Buformin
(therapeutic use)
- Carnosine
(analogs & derivatives, therapeutic use)
- Diabetes Mellitus, Experimental
(drug therapy)
- Diterpenes
(pharmacology, therapeutic use)
- Glyburide
(therapeutic use)
- Hypoglycemic Agents
(therapeutic use)
- Male
- Plant Extracts
(therapeutic use)
- Rats
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