Heterogeneity of monoclonal immunoglobulins with antistreptolysin-O activity detected in the cases of essential monoclonal gammopathy and multiple myeloma.

Abstract

Two different types of monoclonal human immunoglobulins (M-components) with antistreptolysin-O (ASO) activity were investigated. The M-component FM with essential monoclonal gammopathy revealed to have an ASO activity, demonstrated not only by streptolysin-O neutralizing assay according to Ranz-Randall's method, but also by passive agglutination assays and precipitation on agar. The ASO activity was shown to reside in the Feb. These findings suggest that the M-component FM have a true antibody activity. On the other hand, ASO activity of M-component TT with multiple myeloma was detected only by streptolysin-O neutralizing assay, but the passive agglutinating assays and precipitation on agar showed no positive results. It has not been fully confirmed if the M-component TT behaves as a true antibody activity. Heterogeneity of the M-components with ASO activity was discussed.

• Authors: H Ohtani, Y Uchiyama, A Nishida, Y Kano, S Yamamoto
• Journal: The Kitasato archives of experimental medicine (Kitasato Arch Exp Med) Vol. 65 Issue 2-3 Pg. 123-30 (Sep 1992) ISSN: 0023-1924 [Print] Japan
• PMID: 1308253 (Publication Type: Journal Article)

Chemical References

• Bacterial Proteins
• Immunoglobulins
• Streptolysins
• streptolysin O

Topics

• Aged
• Bacterial Proteins
• Female
• Humans
• Hypergammaglobulinemia (immunology)
• Immunoglobulins (immunology)
• Male
• Middle Aged
• Multiple Myeloma (immunology)
• Streptolysins (immunology)