Relevance of plasma fibrinogen estimation in obstetric complications.

Abstract

We present a study of fibrinogen levels in 133 patients who were prone to develop disseminated intravascular coagulation as a result of an underlying complication of pregnancy such as abruptio placentae, pregnancy-induced hypertension, missed abortion, septic abortion, intrauterine fetal death, vesicular mole and amniotic fluid embolism. A high incidence of hypofibrinogenemia was found in cases of abruptio placentae (43.9%) and pregnancy-induced hypertension (25%). Hypofibrinogenemia occurred in 10% cases of intrauterine fetal death within 4 weeks of fetal demise. The use of this simple investigation makes possible the diagnosis of hemostatic failure and also helps to guide replacement therapy during the fibrinopenic state. There were 4 maternal deaths and 12 perinatal losses in this study.

• Authors: H Parasnis, B Raje, I N Hinduja
• Journal: Journal of postgraduate medicine (J Postgrad Med) 1992 Oct-Dec Vol. 38 Issue 4 Pg. 183-5 ISSN: 0022-3859 [Print] India
• PMID: 1307590 (Publication Type: Journal Article)

Chemical References

• Fibrinogen

Topics

• Abruptio Placentae (complications, epidemiology)
• Disseminated Intravascular Coagulation (blood, complications, epidemiology)
• Female
• Fetal Death (epidemiology)
• Fibrinogen (analysis)
• Humans
• Hypertension (complications, epidemiology)
• Incidence
• Pregnancy
• Pregnancy Complications, Cardiovascular (epidemiology)
• Pregnancy Complications, Hematologic (blood, epidemiology)
• Pregnancy Outcome
• Prospective Studies
• Risk Factors