| Abstract | All tetracycline preparations seem to be systemically effective in acne. Quality and frequency of their side-effects, however, are different and should be carefully considered in each individual case. In an own study ninety-one patients treated with minocycline showed good response in 69% and moderate or no response in 31+. The main side-effects of the drug were nausea and giddiness, being of short duration in most cases. In patients with no response to a certain preparation change of the preparation may be helpful. Occasionally, acne does not respond to any tetracycline derivative. In these cases the use of non-tetracycline antibiotics, particularly of trimethoprim-sulphamethazol and lincomycines, is clearly effective. As a rule, we start treatment with tetracycline (500-750 mg/d) and reduce the dose to a minimum (ca. 100 mg/d), in order to withdraw the drug. In non-responsive cases another derivative and/or finally non-tetracycline antibiotics are administered for therapy. |
| Authors | M Kurka, C E Orfanos |
| Journal | Zeitschrift für Hautkrankheiten
(Z Hautkr)
Vol. 51
Issue 2
Pg. 45-54
(Jan 15 1976)
ISSN: 0301-0481 GERMANY, WEST |
| Vernacular Title | Welche Antibiotika helfen bei Akne? Eine Ubersicht der Literatur und eigene Prüfungsergebnisse mit Minocyclin (Klinomycin) |
| PMID | 130738
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Anti-Bacterial Agents
- Tetracyclines
- Minocycline
|
| Topics |
- Acne Vulgaris
(drug therapy)
- Adolescent
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Humans
- Male
- Minocycline
(adverse effects, therapeutic use)
- Tetracyclines
(therapeutic use)
|
