Abstract |
Antitumor polyoxomolybdates have been recognized in the course of study on the medical utilization of polyoxometalates, inorganic polymers of metal oxide. [ NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representative of antitumor polyoxomolybdates. The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nude mice. Polyoxomolybdate is a new type of antitumor substance.
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Authors | H Fujita, T Fujita, T Sakurai, T Yamase, Y Seto |
Journal | The Tohoku journal of experimental medicine
(Tohoku J Exp Med)
Vol. 168
Issue 2
Pg. 421-6
(Oct 1992)
ISSN: 0040-8727 [Print] Japan |
PMID | 1306330
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Breast Neoplasms
(drug therapy, pathology)
- Colonic Neoplasms
(drug therapy, pathology)
- Female
- Humans
- Lung Neoplasms
(drug therapy, pathology)
- Mice
- Mice, Nude
- Models, Molecular
- Molybdenum
(therapeutic use)
- Neoplasm Transplantation
- Oxides
(therapeutic use)
- Subrenal Capsule Assay
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