[The therapeutic efficacy of alloxime in experimental carbamate pesticide poisoning].

Abstract

The new cholinesterase reactivator alloxime, 10 mg/kg, shows a marked therapeutical benefits in acute intoxication rats with carbamine pesticides such as carbofuran, pirimor, elocron. The therapy of alloxime in combination with atropine, 10 mg/kg, results to their combined therapeutical effect, the toxicity of carbofuran, elocron, and pirimor (by LD50) decreasing by 8.4, 5.6, and 3.5 times, respectively). The mechanism of alloxime's therapeutical action is due to its capacity to restore cholinesterase activity in the central nervous system, normalizing neuromuscular transmission and hepatic and renal cytochrome P-450 levels.

• Authors: N V Kokshareva
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1992 Nov-Dec Vol. 55 Issue 6 Pg. 51-3 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Terapevticheskaia éffektivnost' alloksima pri éksperimental'noĭ intoksikatsii karbaminovymi pestitsidami.
• PMID: 1305879 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• Carbamates
• Cholinesterase Reactivators
• Insecticides
• Pyridinium Compounds
• Pyrimidines
• pirimicarb
• dioxacarb
• Atropine
• alloxime
• Carbofuran

Topics

• Acute Disease
• Animals
• Antidotes (therapeutic use)
• Atropine (therapeutic use)
• Carbamates (poisoning)
• Carbofuran (poisoning)
• Cholinesterase Reactivators (therapeutic use)
• Drug Evaluation, Preclinical
• Drug Synergism
• Drug Therapy, Combination
• Insecticides (poisoning)
• Poisoning (drug therapy, etiology)
• Pyridinium Compounds (therapeutic use)
• Pyrimidines
• Rats