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[The effect of bonnecor on blood coagulability and thrombocyte aggregation in transient myocardial ischemia].

Abstract
The experiments on conscious rabbits have indicated that bonnecor given in doses of 0.05 mg/kg and 0.5 mg/kg accelerates clot formation and platelet aggregation, without changing the density of a thrombus. In experimental transient myocardial ischemia, the agent decreases the hypercoagulative change associated with the damaging effect of occlusion and reperfusion.
AuthorsS V Denisova, A V Sapozhkov
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1992 Nov-Dec Vol. 55 Issue 6 Pg. 29-31 ISSN: 0869-2092 [Print] Russia (Federation)
Vernacular TitleVliianie bonnekora na svertyvaemost' krovi i agregatsiiu trombotsitov v usloviiakh tranzitornoĭ ishemii miokarda.
PMID1305870 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Anti-Arrhythmia Agents
  • Dibenzazepines
  • tiracizine
Topics
  • Animals
  • Anti-Arrhythmia Agents (pharmacology, therapeutic use)
  • Blood Coagulation (drug effects)
  • Dibenzazepines (pharmacology, therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Female
  • Male
  • Myocardial Ischemia (blood, drug therapy)
  • Platelet Aggregation (drug effects)
  • Rabbits
  • Time Factors

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