[The interorgan distribution of tritium-labelled para-aminobenzoic acid in the body of rats after its subcutaneous injection].

Abstract

To study the pharmacokinetics of para-aminobenzoic acid (PABA), rats were subcutaneously injected with 3H-PABA (1 mkg/g body weight) at the stage (P7) when stimulation of outer segments of the photoreceptor cell morphogenesis is possible (Stroeva et al., 1990). The maximum labelling assayed for radioactivity by scintillation counting was observed in the liver 3 h after the injection while, in the blood the labelling was 3 times lower and, in the retina, one order lower than in the liver and blood. The label was detected in all the three types of tissue in 24 and 48 hours, being reduced by an order in comparison with each previous term of measurement. Biological structures binding 3H-PABA were not determined in the present study.

• Authors: O G Stroeva, A V Ershov, V A Poplinskaia, I G Panova
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 1992 May-Jun Issue 3 Pg. 459-62 ISSN: 1026-3470 [Print] Russia (Federation)
• Vernacular Title: Mezhorgannoe raspredelenie mechennoĭ tritiem para-aminobenzoĭnoĭ kisloty v organizme krysy posle podkozhnoĭ in''ektsii.
• PMID: 1304852 (Publication Type: English Abstract, Journal Article)

Chemical References

• Tritium
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (administration & dosage, pharmacokinetics)
• Animals
• Injections, Subcutaneous
• Liver (metabolism)
• Rats
• Retina (metabolism)
• Scintillation Counting
• Time Factors
• Tissue Distribution
• Tritium