[Leopard spot chorioretinopathy. Initial manifestation of recurrent acute lymphocytic leukemia].

Abstract

An 11-year-old girl with a history of acute lymphocytic leukemia of the central nervous system had attained complete remission for almost 3 1/2 years after combination chemotherapy and radiotherapy when she developed iritis and chorioretinopathy of the right eye. Neither an anterior chamber tap nor a diagnostic vitrectomy revealed leukemic cells. Both nonspecific anti-inflammatory therapy and antiviral treatment were unsuccessful. Finally, lymphoblasts were detected in the cerebrospinal fluid and in the bone marrow after repeated lumbar puncture and bone marrow aspiration. Combination chemotherapy alone was resumed, resulting in the resolution of all acute ocular symptoms and bone marrow involvement. Only the leopard-spot-like pigmentary fundus changes persisted. The child has now remained in continuous complete remission for 1 1/2 years.

• Authors: W Schimmelpfennig, R J Aur
• Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 89 Issue 5 Pg. 430-1 (Oct 1992) ISSN: 0941-293X [Print] Germany
• Vernacular Title: Leopardenfleck-Chorioretinopathie. Erstes Anzeichen eines Rezidivs einer akuten lymphozytischen Leukämie.
• PMID: 1304225 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child, Preschool
• Choroid Neoplasms (drug therapy, radiotherapy, secondary)
• Combined Modality Therapy
• Cranial Irradiation
• Eye Neoplasms (drug therapy, radiotherapy, secondary)
• Female
• Follow-Up Studies
• Humans
• Pigment Epithelium of Eye (pathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis, drug therapy, radiotherapy)
• Retinal Diseases (diagnosis, drug therapy, radiotherapy)
• Retinal Necrosis Syndrome, Acute (diagnosis, drug therapy, radiotherapy)