Effect upon plaque formation and gingivitis of a triclosan/copolymer/fluoride dentifrice: a 6-month clinical study.

Abstract

A total of 159 adult male and female subjects between 18 and 63 years of age, were entered into a 6-month, double-blind clinical study to assess the effects of a dentifrice containing 0.3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on supragingival plaque formation and gingivitis, as compared to a placebo dentifrice. Both the triclosan and placebo dentifrices contained 0.243% sodium fluoride in a silica base. The subjects had to demonstrate at least mild gingivitis (modified Loe-Silness score > or = 1.0), be free of advanced periodontal disease, have a modified Quigley-Hein Plaque Index score of at least 1.5 and have a minimum of 20 natural, uncrowned teeth. The subjects were stratified into two balanced groups according to baseline plaque and gingivitis scores. At zero time or baseline, all subjects received a complete and thorough oral prophylaxis and were assigned to the use of either the placebo dentifrice or the triclosan/copolymer dentifrice for the next 6 months. Subjects were evaluated for gingivitis and supragingival plaque formation after 3 and 6 months product use. After 3 months, when compared to the placebo dentifrice, the triclosan/copolymer dentifrice provided the following statistically significant reductions (at 99% confidence levels): (1) a 10.0% reduction in supragingival plaque formation; (2) a 20.8% reduction in plaque formation on tooth surfaces with highest baseline plaque scores; (3) a 21.9% reduction in gingivitis, and (4) 30.5% less sites with severe gingivitis, i.e. gingival bleeding.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: J L Denepitiya, D Fine, S Singh, W DeVizio, A R Volpe, P Person
• Journal: American journal of dentistry (Am J Dent) Vol. 5 Issue 6 Pg. 307-11 (Dec 1992) ISSN: 0894-8275 [Print] United States
• PMID: 1304177 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Dentifrices
• Maleates
• Polyvinyls
• polyvinylmethoxyethylene-maleic anhydride copolymer
• Triclosan

Topics

• Adolescent
• Adult
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Dentifrices (therapeutic use)
• Double-Blind Method
• Female
• Gingivitis (prevention & control)
• Humans
• Longitudinal Studies
• Male
• Maleates (therapeutic use)
• Middle Aged
• Periodontal Index
• Polyvinyls (therapeutic use)
• Triclosan (therapeutic use)