This two-phase experiment assessed the effects over time of a
solution containing 1.09%
sodium fluoride, .40%
stannous fluoride, and .14%
hydrogen fluoride (.717%
fluoride solution,
DentinBloc) on
pain associated with dentinal
hypersensitivity. During phase I, 30 subjects demonstrating dentinal
hypersensitivity to a blast of cool air were divided into three double blind experimental groups. After baseline data were collected for all subjects, one group was instructed to apply the .717%
fluoride solution twice a day. A second group was instructed to apply a gel containing .04%
stannous fluoride (
Gel-Kam) twice a day. A third group was instructed to apply distilled water. Each subject was assessed at 2, 4, 8, and 16 weeks utilizing the "method of limits" with a standardized, repeatable cold thermal stimulus. The results of a two factor repeated ANOVA indicated that those subjects who applied the .717%
fluoride solution reported significantly less sensitivity at the 2-week period than the other groups (P < .05). In addition, those subjects whose
solution contained the 0.4%
stannous fluoride reported significantly less sensitivity at the 4- to 8-week periods (P < .05). Phase II of the study assessed the .717%
fluoride solution on a more precise time course. These included: immediately, 15 minute, 1 day, 1 week and 2 weeks. A one factor repeated ANOVA revealed that this effect presented 15-minute post application (P < .05) and continued throughout the testing periods. It was concluded that the fully active 0.717%
fluoride solution was an effective agent in the control of dentinal
hypersensitivity after two 1-minute applications.