Twice daily 4% Sodium Cromoglycate vs. 2% Sodium Cromoglycate used four times daily in seasonal (grass pollen) allergic conjunctivitis.

Abstract

It is well established that 2% Sodium Cromoglycate is an effective treatment for a number of allergic eye diseases. It has been shown to be non-toxic. It can be used longterm and in serious allergic problems it is a useful adjunctive therapy to steroids. The main problem with Sodium Cromoglycate is that the recommended dosage is a four times daily application and patient non-compliance is common. One of the main objectives of any therapy is to reduce the frequency of dosage and the current study has been designed to investigate the efficacy of a 4% solution of Sodium Cromoglycate, used twice daily, versus a 2% solution used four times daily in seasonal allergic conjunctivitis. A multicentre study, therefore, was carried out to assess the efficacy of both drugs and to assess any possibility of side effects. In addition, a unit dose was used, thus eliminating preservatives and it was used specifically in seasonal allergic conjunctivitis in the pollen season. This study showed that 4% Sodium Cromoglycate used twice daily was at least as affective as 2% Sodium Cromoglycate used four times daily.

• Authors: L M Collum, S Fitzsimon, M Hillery, A Collum, W J Power, Z Pelikan, J B Jenson
• Journal: Documenta ophthalmologica. Advances in ophthalmology (Doc Ophthalmol) Vol. 82 Issue 3 Pg. 267-77 ( 1992) ISSN: 0012-4486 [Print] Netherlands
• PMID: 1303863 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Cromolyn Sodium

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Conjunctivitis, Allergic (drug therapy)
• Cromolyn Sodium (administration & dosage, therapeutic use)
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Seasons