[Late effort induced asthmatic response in patients with atopic bronchial asthma after administration of cromoglycate disodium with concurrent evaluation of neutrophil chemotactic factor (NCG) in serum].

Abstract

To evaluate an effect of Intal on the late post-provocation bronchospasm in 30 patients with atopic asthma (with early bronchospasm) the treatment was accompanied by the assessment of NCF activity (as a marker of mastocytes degranulation. It was shown that after therapy with Intal exerted an effect on the NCF activity not only in the early but also late bronchospasm in comparison with its activity in patients after exercise test but prior to therapy--9/22 and 6/29. The authors share an opinion tha the presence of NCF in part of patients with the late postexercise bronchospasm (treated with Intal) may indicate that its origin is different (not from mastocytes).

• Authors: W Grabski, J Rozniecki, J Grzegorczyk
• Journal: Pneumonologia i alergologia polska (Pneumonol Alergol Pol) Vol. 60 Issue 11-12 Pg. 43-7 ( 1992) ISSN: 0867-7077 [Print] Poland
• Vernacular Title: Późny powysiłkowy skurcz oskrzeli u chorych na astme atopowa po stosowaniu kromoglikanu dwusodowego z równoczesna ocena aktywności czynnika chemotaktycznego dla neutrofilów (NCF) w surowicy krwi.
• PMID: 1303777 (Publication Type: English Abstract, Journal Article)

Chemical References

• Interleukin-8
• Cromolyn Sodium

Topics

• Asthma (blood, diagnosis, drug therapy)
• Bronchial Provocation Tests
• Cromolyn Sodium (therapeutic use)
• Exercise Test
• Humans
• Interleukin-8 (blood)