A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne.

Abstract

Alpha hydroxy acids (AHA's) or "fruit acids" are a special group of organic acids found in many natural foods. They have been described in the literature for the treatment of a number of conditions in which abnormal keratinization consistently contributes to pathogenesis. These include the icthyoses, warts, psoriasis, eczema and acne. We have performed a double-blind clinical trial on 150 patients to evaluate the efficacy and skin tolerance of the alpha hydroxy acid gluconolactone 14% in solution (Nuvoderm lotion) in the treatment of mild to moderate acne when compared with its vehicle (placebo) and 5% benzoyl peroxide lotion. The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed). Furthermore, fewer side-effects were experienced by patients treated with gluconolactone when compared with benzoyl peroxide.

• Authors: M J Hunt, R S Barnetson
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 33 Issue 3 Pg. 131-4 ( 1992) ISSN: 0004-8380 [Print] Australia
• PMID: 1303072 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gluconates
• Lactones
• Placebos
• Benzoyl Peroxide
• beta-glucono-1,5-lactone

Topics

• Acne Vulgaris (drug therapy, pathology)
• Administration, Cutaneous
• Adolescent
• Adult
• Benzoyl Peroxide (administration & dosage, adverse effects, therapeutic use)
• Double-Blind Method
• Female
• Gluconates (administration & dosage, adverse effects, therapeutic use)
• Humans
• Lactones
• Male
• Placebos
• Prospective Studies
• Skin (drug effects, pathology)
• Skin Diseases (chemically induced)
• Time Factors