[The anticarcinogenic effects of fumaric acid on models of carcinogenesis in the esophagus, nervous system and kidney].

Abstract

Anticarcinogenic effects of the fumaric acid was studied in two rat models of carcinogenesis. Tumors of the esophagus, forestomach, tongue and throat were induced by peroral instillation of 35 mg/kg body weight N-methyl-N-benzylnitrosamine, and neurogenic and renal ones--by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. The fumaric acid given in drinking water in the dose of 1 g/l at the postinitiation stage of the carcinogenesis was shown to inhibit the development of esophageal papilloma, brain glioma and mesenchymal tumors of the kidney.

• Authors: V G Bespalov, V A Aleksandrov, A S Petrov, D N Troian
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 38 Issue 8 Pg. 956-61 ( 1992) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Izuchenie antikantserogennykh éffektov fumarovoĭ kisloty na modeliakh kantserogeneza v pishchevode, nervnoĭ sisteme i pochke.
• PMID: 1300806 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Fumarates
• fumaric acid
• nitrosobenzylmethylamine
• Dimethylnitrosamine
• Ethylnitrosourea

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Carcinogens
• Chi-Square Distribution
• Dimethylnitrosamine (analogs & derivatives)
• Disease Models, Animal
• Drug Screening Assays, Antitumor
• Esophageal Neoplasms (chemically induced, epidemiology, prevention & control)
• Ethylnitrosourea
• Female
• Fumarates (therapeutic use)
• Kidney Neoplasms (chemically induced, epidemiology, prevention & control)
• Male
• Nervous System Neoplasms (chemically induced, epidemiology, prevention & control)
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats