[The inhibiting effect of epsilon-aminocaproic acid on the incidence of induced tumors of the esophagus, nervous system and kidneys].

Abstract

The anticarcinogenic properties of epsilon-aminocaproic acid were studied in two rat models of carcinogenesis. Esophageal tumors were induced by oral instillations of a total dose of 54 mg/kg body weight N-methyl-N-benzylnitrosamine whereas tumors of the nervous system and kidney-by transplacental injection of 75 mg/kg body weight N-ethyl-N-nitrosourea. epsilon-Aminocaproic acid given at a concentration of 1 milligram drinking water at the post-initiation stage of the carcinogenesis was shown to inhibit the induction of cancer and papilloma of the esophagus, brain glioma, peripheral nerve neurinoma and mesenchymal tumors of the kidney.

• Authors: V G Bespalov, V A Aleksandrov, A S Petrov, D N Troian
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 38 Issue 1 Pg. 69-74 ( 1992) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Tormoziashchee vliianie épsilon-aminokapronovoĭ kisloty na chastotu indutsirovannykh opukholeĭ pishchevoda, nervnoĭ sistemy i pochek.
• PMID: 1300690 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• nitrosobenzylmethylamine
• Dimethylnitrosamine
• Ethylnitrosourea
• Aminocaproic Acid

Topics

• Aminocaproic Acid (therapeutic use)
• Animals
• Anticarcinogenic Agents (therapeutic use)
• Carcinogens
• Chi-Square Distribution
• Dimethylnitrosamine (analogs & derivatives)
• Drug Screening Assays, Antitumor
• Esophageal Neoplasms (chemically induced, epidemiology, prevention & control)
• Ethylnitrosourea
• Female
• Incidence
• Kidney Neoplasms (chemically induced, epidemiology, prevention & control)
• Male
• Nervous System Neoplasms (chemically induced, epidemiology, prevention & control)
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats