Transamination in the metabolism of beta-2-thienyl-DL-alanine in normal and neoplastic cells in vitro.

Abstract

In tissue cultures of C-57 black mouse heart and sarcoma T-241, beta-2-thienyl-DL-alanine acts specifically as a phenylalanine antagonist. Heart cultures can transaminate between beta-2-thienyl-DL-alanine and phenylpyruvate to form L-phenylalanine and thus block the toxic action of the remaining beta-2-thienyl-DL-alanine, whereas sarcoma T-241 cultures cannot. Of eleven mouse tumors and four rat tumors tested for their ability to perform this reaction, nine tumors had little or no activity. The beta-2-thienylpyruvic acid resulting from transamination further reacts to form a red compound the exact structure of which is not yet known.

• Authors: J A JACQUEZ, R K BARCLAY, C C STOCK
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 96 Issue 5 Pg. 499-512 (Nov 1952) ISSN: 0022-1007 [Print] United States
• PMID: 13000060 (Publication Type: Journal Article)

Chemical References

• beta-Alanine
• Alanine

Topics

• Alanine (analogs & derivatives)
• Animals
• In Vitro Techniques
• Mice
• Neoplasms, Experimental
• Rats
• beta-Alanine