Abstract |
A 7-month-old girl with acute biphenotypic leukemia [t(4;11)] had accompanying anemia, thrombocytopenia, and a white blood cell count of 535,000/microL with 98% blasts. Before instituting chemotherapy, therapeutic leukapheresis was done to reduce the threat of complications from leukostasis. Using a Cobe Spectra blood cell separator primed with modified blood, we processed 1,395 mL of her blood, removing 201 mL of the buffy coat containing 5.8 x 10(10) white blood cells. This reduced the WBC count to 301,000/microL. Only a single procedure was done, without significant complications. The rationale of this preparatory cytoreduction is discussed critically. Subsequent chemotherapy resulted in a long-lasting remission.
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Authors | D W Huestis, J J Hutter Jr, P James |
Journal | Journal of clinical apheresis
(J Clin Apher)
Vol. 7
Issue 4
Pg. 191-3
( 1992)
ISSN: 0733-2459 [Print] United States |
PMID | 1299657
(Publication Type: Case Reports, Journal Article)
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Topics |
- Acute Disease
- Cell Separation
- Female
- Humans
- Infant
- Leukapheresis
- Leukemia
(complications, therapy)
- Leukocytosis
(etiology, therapy)
- Remission Induction
(methods)
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