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Changes in endogenous prostacyclin in the rat brain during clinical death and after resuscitation.

Abstract
By means of the radioimmunologic method changes of concentration of 6-keto-prostaglandin F1 alpha (PGF1 alpha)--the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation. Ischemia did not produce significant changes of 6-keto-PGF1 alpha concentration in the brain. In the early postresuscitation period the concentration of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1 alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.
AuthorsA Kapuściński
JournalNeuropatologia polska (Neuropatol Pol) Vol. 30 Issue 2 Pg. 127-32 ( 1992) ISSN: 0028-3894 [Print] Poland
PMID1297927 (Publication Type: Journal Article)
Chemical References
  • 6-Ketoprostaglandin F1 alpha
  • Epoprostenol
Topics
  • 6-Ketoprostaglandin F1 alpha (analysis)
  • Animals
  • Brain Chemistry
  • Brain Ischemia (drug therapy, metabolism)
  • Cerebrovascular Disorders (drug therapy)
  • Epoprostenol (pharmacology, therapeutic use)
  • Female
  • Radioimmunoassay
  • Rats
  • Rats, Wistar
  • Resuscitation

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