Abstract |
By means of the radioimmunologic method changes of concentration of 6-keto-prostaglandin F1 alpha (PGF1 alpha)--the stable metabolite of prostacyclin in the rat brain have been evaluated during 5-min clinical death and up to 2 hrs after resuscitation. Ischemia did not produce significant changes of 6-keto-PGF1 alpha concentration in the brain. In the early postresuscitation period the concentration of 6-keto-PGF1 in the and 7-fold control values. Later the concentration of 6-keto-PGF1 alpha in the brain decreased reaching in 30 min a 3-fold the control level, and in 60 and 120 min after resuscitation control values. The reasons of unsuccessful therapy of ischemic stroke with prostacyclin are discussed.
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Authors | A Kapuściński |
Journal | Neuropatologia polska
(Neuropatol Pol)
Vol. 30
Issue 2
Pg. 127-32
( 1992)
ISSN: 0028-3894 [Print] Poland |
PMID | 1297927
(Publication Type: Journal Article)
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Chemical References |
- 6-Ketoprostaglandin F1 alpha
- Epoprostenol
|
Topics |
- 6-Ketoprostaglandin F1 alpha
(analysis)
- Animals
- Brain Chemistry
- Brain Ischemia
(drug therapy, metabolism)
- Cerebrovascular Disorders
(drug therapy)
- Epoprostenol
(pharmacology, therapeutic use)
- Female
- Radioimmunoassay
- Rats
- Rats, Wistar
- Resuscitation
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